Therapy of gram-negative infection in the complex treatment of cystic fibrosis

Chronic lung infections are a consequence of the disturbance mucociliary clearance process in cystic fibrosis. For most patients with fibrosis, chronic infection is associated poor prognosis. The impact Pseudomonas aeruginosa on progressive deterioration function and nutritional status has been established. Timely effective antibiotic therapy aimed at eradication or control gram-negative flora affects duration quality life. purpose study . To investigate safety efficacy inhaled administration sodium colistimethate (Colimistin®). Methods enrolled 42 (27 aged 5 to 17 years 15 over 18 years) an established diagnosis 38 monoculture P. various associations, 4 Achromobacter spp culture. Microbial status, external respiratory function, assessment well-being, adverse reactions, exacerbations, use during colimistin inhalations were recorded all baseline 3 months. Results A significant improvement terms weight ( p < 0.007) height 0.001) was shown general patient group children’s group. In children, there increase 0.034) 0.0001). older than years, 0.045) BMI three months after 0.013). There no improvements FVC FEV1. treatment by well-being 0.002). No difference found adult 0.067). Two dropped out due ADR start therapy. Conclusion Sodium showed bronchopulmonary caused association may be recommended for children adults